TP53 and Barrett esophagus: This is demonstrated by the observation of infrequent arm-level or large segmental SCNAs in single BE cells (Fig. 3) and even instances of chromothripsis in BE clones (e.g., on chr9p in patient 8 BE1-3, patient 11 LGD, and patient 6, all samples) inferred to have occurred prior to TP53 inactivation.