By contrast, focal deletion near FHIT (a common fragile site) is often ancestral to all BE and EAC lesions; bi-allelic inactivation of CDKN2A (a frequently inactivated tumor suppressor) can be truncal to either cancer/HGD lesions (patient 3, 5, 6, and 7) or NDBE/LGD lesions (patients 2, 8, 9, 11, and 14). This evidence concerns the gene CDKN2A and Barrett esophagus.