VEGFA and wet macular degeneration: In the CPRs, SDM has been found to improve retinal and visual function by all measures in dry AMD, open angle glaucoma and inherited retinal degenerations; reverse progression of diabetic retinopathy; effectively treat diabetic macular edema and central serous chorioretinopathy; reverse tolerance to anti-VEGF medications in wet AMD; and slow progression of age-related geographic atrophy1–23.