MBD2 and acute myeloid leukemia: Using whole genome bisulfite sequencing (WGBS), we observed a global increase in DNA methylation in CebpaΔ/p30Tet2Δ/Δ vs. CebpaΔ/p30Tet2+/+ AML blasts, consistent with a loss of demethylase activity in Tet2 knockout blasts (Fig. 3d).