To study the effect of TET2 mutations in CEBPADM AML in pathophysiologically relevant in vitro and in vivo models, we utilized cell and murine models in which expression of the p30 isoform is retained (Cebpap30/p30 or CebpaΔ/p30), while the normal p42 isoform of CEBPA is completely lost13. Here, CEBPA is linked to acute myeloid leukemia.