For CEBPADM AML, co-occurring lesions have been found in genes such as GATA2, TET2, WT1, FLT3, and CSFR3. While the mechanistic basis for the cooperation between CEBPA and GATA2/CSFR3 mutations has been investigated using mouse models14,15, we have very little insight into why other lesions, such as those in TET2, are overrepresented in CEBPADM AML. Here, GATA2 is linked to acute myeloid leukemia.