Importantly, whereas mutations in WT1 followed the same pattern as TET2, CSF3R mutations appeared in equal frequency between TET2MUTCEBPADM and TET2WTCEBPADM AML cases, and ASXL1 mutations were increased in TET2MUTCEBPADM AML (Supplemental Fig. 4f; Supplemental Table 2c–e). This evidence concerns the gene ASXL1 and acute myeloid leukemia.