In summary, we show that the demethylating agent 5-AZA can restore Gata2 expression levels in TET2-deficient CebpaDM AML to that of TET2-proficient CebpaDM AML, and concomitantly reduce leukemic burden and prolong survival of mice transplanted with TET2-deficient CebpaDM leukemic blasts. Here, TET2 is linked to acute myeloid leukemia.