An equally important role for CEBPA is observed in the context of inv(3) and t(3;3) AML in which inversions, translocations, and rearrangements involving the EVI1 gene at the MECOM locus, lead to hijacking of the G2DHE to promote EVII expression at the expense of GATA2 expression thus resulting in GATA2 haploinsufficiency55–58. This evidence concerns the gene MECOM and acute myeloid leukemia.