In line with this, specifically the Gata2 V2 mRNA isoform was downregulated in TET2-deficient CebpaDM AML blasts (−86%; Fig. 3g), while changes in mRNA expression and promoter methylation of Gata2 V1 did not reach statistical significance (Fig. 3f, g). The gene discussed is GATA2; the disease is acute myeloid leukemia.