FLT3 and acute myeloid leukemia: For CEBPADM AML, co-occurring lesions have been found in genes such as GATA2, TET2, WT1, FLT3, and CSFR3. While the mechanistic basis for the cooperation between CEBPA and GATA2/CSFR3 mutations has been investigated using mouse models14,15, we have very little insight into why other lesions, such as those in TET2, are overrepresented in CEBPADM AML.