Further, the G2DHE has been shown to primarily regulate expression of the hematopoietic specific Gata2 variant 2 (V2)40,41, conforming with our data that particularly the Gata2 V2 promoter displayed an increase in DNA methylation and that the Gata2 V2 mRNA was downregulated in TET2-deficient CebpaDM AML blasts (Fig. 3f–g). Here, TET2 is linked to acute myeloid leukemia.