In conclusion, our results reveal that GATA2 is a conserved target of the CEBPA-TET2 mutational axis in CEBPADM AML and we propose an intricate mechanism by which elevated CEBPA p30 levels mediate recruitment of TET2 to regulatory regions of the Gata2 gene to promote its expression. The gene discussed is CEBPA; the disease is acute myeloid leukemia.