For example, we know that two genes previously implicated in AD, FLG and CD2072,18 are predominantly expressed in the skin and in our gene prioritisation investigations there was no evidence from blood linking FLG to the rs61816766 association and only one analysis of monocytes separated from peripheral blood mononuclear cell (PBMC) samples28 which implicated CD207 for the rs112111458 association, amongst an abundance of evidence from skin for both genes playing a role in AD (Supplementary Data 11). The gene discussed is FLG; the disease is Alzheimer disease.