Validation assays of MUC13 IP with MUC13 antibody (Fig S4Ai), YAP1 IP with YAP1 antibody (Fig S4Aii), and reverse co-IP of YAP1 with anti-MUC13 antibody in SW620 cells, and co-IP of MUC13 with anti-YAP1 antibody were performed as shown in Fig S4B and C, to show MUC13 and YAP1 interaction in different cancer cell lines. Here, YAP1 is linked to cancer.