Recent studies reported MUC13-mediated activation of Wnt/β-catenin signaling in liver cancer (Dai et al, 2018), cross-talk of β-catenin, and Hippo-YAP1 signaling pathways in cancer (Fang et al, 2000; Konsavage et al, 2012; Bernascone & Martin-Belmonte, 2013; Herbst et al, 2014; Sanchez-Vega et al, 2018). The gene discussed is YAP1; the disease is liver cancer.