The following nine pathways were inhibited on day 1 but activated on day 7 of OHT: synaptogenesis signaling pathway, neurovascular coupling signaling pathway, glutathione redox reactions I, xenobiotic metabolism general signaling pathway, polyamine regulation in colon cancer, glutathione-mediated detoxification, RHOA signaling, Reelin signaling in neurons, and Fcγ receptor–mediated phagocytosis in macrophages and monocytes. The gene discussed is RELN; the disease is colonic neoplasm.