Among the pathways that were not activated until day 7, including signaling by Rho family GTPases, Reelin signaling in neurons, synaptogenesis signaling pathway, cardiac hypertrophy signaling (Enhanced), Fcγ receptor–mediated phagocytosis in macrophages and monocytes, Ephrin receptor signaling, actin cytoskeleton signaling, remodeling of epithelial adherens junctions, thrombin signaling, and IL-8 signaling. The gene discussed is RELN; the disease is cardiac hypertrophy.