REN and pancreatic adenocarcinoma: The pathways inhibited on day 1 but restored to WT level on day 7 of OHT were the PTEN signaling, glutathione-mediated detoxification, super pathway of cholesterol biosynthesis, regulation of actin-based motility by Rho, cholesterol biosynthesis I, and antioxidant action of vitamin C. The pathways that were not activated until day 7 included the senescence pathway, UVB-induced MAPK signaling, CXCR4 signaling, IL-1 signaling, RANK signaling in osteoclasts, renin-angiotensin signaling, and pancreatic adenocarcinoma signaling.