Nonetheless, MR evidence also supports causal associations between three CpGs and cardiometabolic traits in which better diet quality DNAm levels were associated with worse cardiometabolic health markers, which were opposite to what was found in observational EWAS, in particular for cg23761815 (SLC29A3) and cg02650017 (PHOSPHO1) in relation to T2D risk. This evidence concerns the gene SLC29A3 and type 2 diabetes mellitus.