Finally, in the early stages (7 months old) of disease progression in the Tg2576 model of AD, a 7‐day RB5 treatment restored ERK phosphorylation in the hippocampal CA1 and dentate gyrus (Fig 5J and K) and significantly reduced the preapoptotic phenotype measured by caspase‐3 (Fig 5L). Here, MAPK1 is linked to Alzheimer disease.