Similarly, changes in splicing of PKM transcripts are well-documented in a number of disease states, with a switch from the PKM1 isoform towards the PKM2 isoform associated with pulmonary hypertension (Caruso et al. 2017; Zhang, Wang et al. 2017), sporadic Alzheimer's disease (Traxler et al. 2022), and enhancement of the Warburg effect in cancer cells (Israelsen and Vander Heiden 2015). This evidence concerns the gene PKM and cancer.