PKM and pulmonary arterial hypertension: Similarly, changes in splicing of PKM transcripts are well-documented in a number of disease states, with a switch from the PKM1 isoform towards the PKM2 isoform associated with pulmonary hypertension (Caruso et al. 2017; Zhang, Wang et al. 2017), sporadic Alzheimer's disease (Traxler et al. 2022), and enhancement of the Warburg effect in cancer cells (Israelsen and Vander Heiden 2015).