After all, pyruvate kinase deficiency is the most common enzymatic disorder detected in newborns, and a wide variety of disease-causing PKLR variants have been identified (Dolan et al. 2002; Grace et al. 2015; Fattizzo et al. 2022; Luke et al. 2023). Here, PKLR is linked to Hemolytic anemia due to red cell pyruvate kinase deficiency.