CHEK2 and breast cancer: The genetic landscape of the identified PVs was dominated by the BRCA1 gene, followed by the BRCA2, TP53, CHEK2, PALB2, and SDHB genes, and was consistent with the profile of early-onset BC and/or ovarian cancer in the Indian population and in BC patients in the Brazilian miscegenated population, where PVs in the BRCA1 gene were also dominant, followed by the BRCA2 and TP53 genes [23, 24].