PVs in the 12 established BC predisposition genes (ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NF1, PALB2, PTEN, RAD51C, RAD51D, and TP53) were detected in 22.3% of our patient population, which is higher than that reported in the CARRIERS consortium that was a population-based study of hereditary BC genes in the United States (5.03%) [20]. The gene discussed is CHEK2; the disease is breast cancer.