Extracellular matrix degradation is an important process in the growth and invasion of malignant tumors (Paz et al., 2014), and previous research revealed that KDELR2 can potently enhance extracellular matrix degradation through activation of KDELR-Src pathway (Ruggiero et al., 2015) and enhancement of Golgi-mediated secretion of MMPs (Bajaj et al., 2020). Here, KDELR2 is linked to cancer.