Strikingly, although the reduction in tumor volume by 5 dpi was comparable for LBT070 and LBT070 LGALS1 KO (both ±75% reduction) (Fig 8F), LBT070 LGALS1 KO tumors were much more confined at 5 dpi than the invasive LBT070 tumors (Fig EV5D and E). Here, LGALS1 is linked to neoplasm.