Importantly, the GSCCs used for these experiments cover a broad spectrum of genetic aberrations that are frequently present in GBM (Fig 1B): GSCCs were IDH1‐wildtype with mutations and/or copy number variations in common tumor suppressors and oncogenes such as EGFRamp/mut/Chr7amp, CDKN2Adel, TP53mut, PTENmut/del/Chr10del, CDK4amp, BRAFamp/mut and NF1mut. This evidence concerns the gene IDH1 and glioblastoma.