Clomifene citrate (CC), metformin, and thiazolidinediones [thiazolidinediones (TZDs), e.g., rosiglitazone and pioglitazone] which are often used to increase insulin sensitivity and decrease IR are considered to be the first line ovulation-inducing drugs in infertile women with PCOS either alone or in combination [7-9]. This evidence concerns the gene INS and polycystic ovary syndrome.