SHBG and Hyperinsulinemia: Moreover, insulin, also, acts as an essential part of the regulation of androgen. As insulin gets high, there is going to be a mutual decline in the level of the serum sex hormone binding globulin (SHBG) via inhibiting the liver's form of production of these hormones [19]. Many studies have found that hyperinsulinemia and IR are important outcomes in females suffering from PCOS [21].