In particular, STING-associated vasculopathy with onset in infancy (SAVI) is caused by de novo mutations in TMEM173, the gene encoding STING, and is associated with a type I IFN response signature and increased blood levels of CXCL10 chemokine, a well-known ISG (Liu et al., 2014). This evidence concerns the gene STING1 and STING-associated vasculopathy with onset in infancy.