PUM2 and obesity due to melanocortin 4 receptor deficiency: Patients with obesity often have a slower rate of wound healing, than healthy individuals, and circRNA Circ_0075932, which is a single exon exosome secreted by his/her adipose tissues, can bind to pumilio homolog 2 (PUM2), promoting the expression of serine/threonine protein kinase, activating nuclear factor kappa beta (NF-kB) pathway to induce inflammation and apoptosis, eventually accelerating healing (Zhang X et al., 2019).