CCN2 and esophageal squamous cell carcinoma: We infer from this result that Ezrin may promote ESCC occurrence and development, and its impact on ESCC malignant behavior may occur via up-regulation of YAP1 and CTGF expression in the Hippo pathway; however, our findings cannot fully and accurately explain the mechanism underlying the interaction between Ezrin and other core components of the Hippo pathway, which will be a major aspect of follow-up research on this subject.