Immunohistochemical analysis showed that the positive expression rates of Ezrin, YAP1, and CTGF in paracancer tissues were 23.3, 11.7, and 18.3%, while those in ESCC were 86.7, 91.6, and 88.3%, respectively, displaying significant differences. This evidence concerns the gene YAP1 and esophageal squamous cell carcinoma.