Consistently, the genetic ablation of P2ry2 in hematopoietic cells in P2ry2fl/fl Vav-cre+ mice results in an alleviated HDM-induced airway inflammation in terms of eosinophils in the BALF, production of type 2 cytokine of HDM re-stimulated MLN cells, peribronchial inflammation, and BHR compared to cre-negative littermates. The gene discussed is P2RY2; the disease is inflammatory response.