Thus, renal CXCL9 and CXCL10 are decreased at the transcript and protein levels in lupus prone MRL/lpr Fli-1+/−- mice and suggests FLI-1 modulates CXCL10, CXCL9 expression in the kidneys during lupus nephritis. The gene discussed is CXCL10; the disease is systemic lupus erythematosus.