We showed that globally reducing FLI-1 levels in a lupus prone mouse strain reduced renal Cxcl9 and Cxcl10 gene expression and renal-infiltrating CXCR3+ T cells, and that FLI-1 can upregulate Cxcr3 promoter activity in T cells (27). This evidence concerns the gene CXCL9 and systemic lupus erythematosus.