We found that the significantly activated regulons were involved in T cell biology (RORC, TCF7, NFATC1, and LEF1) or disease pathogenesis (IKZF2 for CD30+ TMF and BATF3 for cALCL) or reported cancer biology (POUZAF1 and TSHZ2) (Figure 3A). This evidence concerns the gene LEF1 and cancer.