CXCR4 and neuroblastoma: The results showed that in FNB, NE cells communicate most closely with Monocytes via MIF-(CD74+CXCR4) and MIF-(CD74+CD44) (Figure 5C), and several ligand receptors including MDK-NCL have important roles in intercellular interactions in TME, which are potential therapeutic targets for NB (Figures 5D–F).