S100B and neoplasm: There were significant differences in the results of Ki-67 (Supplementary Figure 1A, C) and S-100 (Supplementary Figures 1B, D) expression levels between F2 and F2’s sister (Supplementary Figures 1A, B belong to F2; Supplementary Figures 1C, D belong to F2’s sister).Immunohistochemistry showed that the F2 tumor was more indolent, and the tumor cell density, mitosis-karyorrhexis index(MKI), and mitotic index of F2 were all lower than her sister’s tumors.