In our study, iron death was more closely linked to the protective role of STARD12, which may participate in the regulation of nine ferroptosis associated genes including ALOX15, DPP4, GLS2, NCOA4, ATP5MC3, CARS1, CISD1, FANCD2 and SLC7A1 to suppress tumor progression of LUAD. This evidence concerns the gene ALOX15 and neoplasm.