HUC-MSCs attenuated the expression of TGF-β1, α-SMA, collagen I, and heat shock protein 47 (HSP47) mRNA and increased the expression of E-cadherin and bone morphogenetic protein 7 (BMP-7) mRNA, suggesting that HUC-MSCs can prevent renal injury in DN rats via paracrine humoral factors 99, 100. The gene discussed is TGFB1; the disease is liver dysplastic nodule.