TP53 and colorectal cancer: Our analysis showed that the differential intestinal flora between the NHBV and HC groups were mainly enriched in Apoptosis, Cardiac muscle contraction, Parkinson’s disease, Carotenoid biosynthesis, Vasopressin-regulated water reabsorption, p53 pathway, Flavonoid biosynthesis, Influenza A, Toxoplasmosis, Colorectal cancer, Small cell lung cancer and other functional pathways (Figure 3A).