IL7R and Autoimmunity: Regarding inflammatory diseases, Yasunaga et al. developed an ADC targeting IL-7 receptor (IL-7R) conjugated with MMAE and showed that ADC-mediated immunoregulation of the IL-7R, the upregulation of which is a common mechanism in the pathogenesis of autoimmunity, specifically depleted IL-7R-positive cells in the inflammation site of a mouse model of autoimmune arthritis and abrogated disease progression (Yasunaga et al., 2017).