In addition, the treatment of renal cell carcinoma cell lines with sunitinib in vitro increases GRP78 expression, which promotes the proliferation of renal carcinoma cells under hypoxia/hypoglycemia stress and resistance to apoptosis by stimulating PERK/eIF2α signaling (Correia de Sousa et al., 2023). The gene discussed is HSPA5; the disease is renal cell carcinoma.