Apoptosis can be activated by a mitochondrial pathway controlled by interactions between the proapoptotic and antiapoptotic members of the BCL2 family; the Bcl-2 antiapoptotic molecule is frequently upregulated in multidrug-resistant tumor cells to prevent drug-induced apoptosis (Maji et al., 2018; Zhang et al., 2021a). Here, BCL2 is linked to neoplasm.