The association between circulating ghrelin levels and gastric cancer has not been systematically analyzed.<h4>Objective</h4>This work explored the association between circulating ghrelin levels and gastric cancer.<h4>Methods</h4>The literature search for relevant articles published until November 2022 was performed using PubMed, Cochrane Library, EMBASE, and Web of Science with the keywords "ghrelin" and "gastric cancer". The gene discussed is GHRL; the disease is gastric cancer.