Available evidences showed that Tie2 was expressed in immunocytes including DCs, TAMs, T lymphocytes, neutrophils and mast cells, combining with the findings that ANG2 was expressed aberrantly in gliomas, provide us a feasible theoretical basis for further studying the ANG and immune cell interactions in the glioma microenvironment (62, 166–169). This evidence concerns the gene TEK and central nervous system cancer.