We report evidence of PTV association with overall breast cancer risk for BRCA2 and ATM with adjusted ORs of 9.75 (1.81-52.69 95% CI, p-value = 0.0081) and 7.61 (1.32-43.97 95% CI, p-value = 0.023) (Figure 1; Table 2, Supplementary Table S3). The gene discussed is BRCA2; the disease is breast carcinoma.