Of these, 3.54% of cases (n = 35/990) and 0.37% of controls (n = 4/1,094), harbored PTVs in the established breast cancer susceptibility genes ATM, BARD1, BRCA1, BRCA2, CHEK2, PALB2, RAD51C, RAD51D and TP53 (Dorling et al., 2021). This evidence concerns the gene BARD1 and breast carcinoma.