BRCA1 and breast cancer: Moreover, breast cancer patients with PTVs in BRCA1 and BRCA2 had a relatively younger age at diagnosis compared to cases without PTVs in BRCA1 and BRCA2 or cases with PTVs in genes other than BRCA1 and BRCA2. These findings are consistent with recent data suggesting that the prevalence of PVs in genes other than BRCA1 and BRCA2 does not depend on age at diagnosis (Tung et al., 2016; Buys et al., 2017).