BRCA2 and breast carcinoma: Breast cancer cases with PTVs in BRCA1 and BRCA2 had a relatively younger age at diagnosis (46.7 ± 10.4 sd) compared to cases without PTVs in BRCA1 and BRCA2 (51.6 ± 9.3 sd, Wilcoxon rank sum test p-value = 0.046) or cases with PTVs in genes other than BRCA1 and BRCA2 (53 ± 10.9 sd, two-sample t-test p-value = 0.051).