ESR1 and cancer: It has not escaped our notice that many of the highest scoring prioritized targets predicted by our algorithm are also well-established biomarkers of cancer including p53, IL-6, VEGFA, EGFR, NF-KB, ESR1, ERBB2, and others (Pentheroudakis et al., 2019; Wang et al., 2020a; Liebl & Hofmann, 2021; Vainer, Dehlendorff & Johansen, 2018; Wang et al., 2019b; Li et al., 2020; Lupo et al., 2020; Ye et al., 2020; Topi et al., 2022; Bitar et al., 2021).