OTOP2 and colorectal cancer: We also identified multiple down-regulated genes in colorectal cancer that are supported by recent studies on the gene products of the OTOP2 (Qu et al., 2019; Yang & Sakharkar, 2022), OTOP3 (Yang & Sakharkar, 2022), SPIB (Zhao et al., 2021; Liu et al., 2019), and INSL5 genes (Yang et al., 2021c; Sun et al., 2019).