MAPT and Alzheimer disease: In the current research milieu, conjectures proffer that the neuropathological signatures of AD encompass the emergence of amyloid-beta (Aβ) neuritic plaques, the presence of hyperphosphorylated tau protein within neurofibrillary tangles (NFTs), in conjunction with the attrition and debilitation of neuronal constituencies and synaptic junctions (Long and Holtzman, 2019).