INS and lipodystrophy: Interestingly in individuals without T2D, (n = 895,990), we observed that the lipodystrophy (P < 10−17), adiposity (P < 10−8), and elevated insulin secretion (P < 10−9) genetic clusters maintained their associations with increased CAD and MI risk (OR 1.06, P < 10−12) (Fig. 3, Supplementary Table 8).