Top weighted loci in this cluster have been connected to fatty liver disease (GCKR)30 and hepatic glycogen storage (RP11-10A14.4/PPP1R3B) 31–33, and the top-weighted trait was decreased serum triglyceride levels, suggesting that the cluster association with reduced CAD risk might be explained by loci impacting hepatic storage of triglycerides and/or glycogen. The gene discussed is GCKR; the disease is fatty liver disease.