RHOA and systemic lupus erythematosus: RhoA exerts its major functions by activating Rho-associated serine/threonine protein kinases (ROCKs), which include the two isoforms: ROCK1 and ROCK(19).Activation of the RhoA/ROCK pathway in autoimmune disease has been well described, although its specific contribution to SLE is only beginning to emerge (17).