Ten months after the last vaccination, LPL-005 developed a grade 3 non-malignant pleural effusion, grade 1 pericardial effusion, and leukocytopenia, accompanied by an increase in rheumatoid factor (23.1 IU/mL [normal range 0.0–15.9]) and an ANA titer of 1:80; all findings resolved within 2 months. Here, BTG3 is linked to Pleural effusion.