Among the top downregulated genes were FOS, JUN, ATF3, ATF4, NFKBIA and MAP3K8 which are essential for the growth of B lymphocytes 20,21 as well as proteins of the EIF (eukaryotic initiation factor) family (EIF4A1 22, EIF4A2, EIF4A3), GADD34 23, ribosomal protein L family (RPL4, RPL9, RPL13, RPL21, RP23, PRL27, RPL37, RPL38, RPL10A) and ribosomal proteins family (RPS2, RPS6, RPS9, RPS11, RPS16, RPS20, RPS26, RPS27) which are essential for lymphoma cell proliferation and protein synthesis 24 (Fig. 1F, top). The gene discussed is ATF4; the disease is lymphoma.