SOX7 and central nervous system cancer: One study demonstrated that SOX7 was downregulated in human glioma, allowing cancer development through upregulated Wnt/ -catenin signaling (Zhao et al., 2016), whereas another study demonstrated that overexpression of SOX7 in high-grade glioma (HGG) promoted cancer development by promoting tumor growth via vessel abnormalization (Kim et al., 2018).