XRN2 and autism: XRN2 has been found to play a role in regulating miRNA expression in neurons specifically, and altered miRNA expression regulation has been investigated as a potential mechanism for autism susceptibility (Abu-Elneel et al., 2008; Ghahramani Seno et al., 2011; Hicks & Middleton, 2016; Kinjo et al., 2013; Wu et al., 2016).