EIF4EBP1 and Alzheimer disease: Consistent with a role for increased mTORC1 activity in the etiology of AD, we observed increased phosphorylation of T389 S6K1 and T37/S46 4E-BP1 in the brains of control-fed 3xTg female and male mice relative to control-fed NTg mice (Figs. 7A–C, S6A-C).