HLA-G and Miyoshi myopathy: High-risk MM was defined by presence of high b2-microglobulin ( > = 5.5 mg/L) or presence of cytogenetic abnormalities, including t(4;14), t(14;20), t(14;16), deletion (17p) detected by fluorescence in situ hybridization [28], 29% of patients were classified as having high-risk disease.