As noted above, Fibronectin, PAI1 and Caveolin1 are associated with increased GBM malignancy {Seker, 2019 #332; Kabir, 2022 #353; Wu, 2022 #352; Pu, 2019 #357; Moriconi, 2021 #355}. The gene discussed is SERPINE1; the disease is glioblastoma.