Notably, S100A4 is a marker and a regulator of GSCs in a mouse model and is a master regulator of mesenchymal transitions in GBM cells {Chow, 2017 #378} and has recently been identified as a regulator of immune suppressive myeloid and lymphoid cells {Abdelfattah, 2022 #100}. The gene discussed is S100A4; the disease is glioblastoma.