TCF7 and non-small cell lung carcinoma: As in NSCLC, PKM2KO T cells exhibited a central memory-like phenotype, with elevated CD44 + CD62L + proportions at both timepoints in both tissues and enhanced TCF1 and Eomes expression at the later timepoint, marginally in the draining lymph node and significantly in the tumor (Extended Data Fig. 6J-6O).