Strikingly, only 44 (2%) DEGs overlap between our study’s patients with CRLF2 rearrangements and the ones from Roberts, et al. Primarily, this demonstrates the complex gene expression patterns in these ALL patients that changes significantly depending on age and ethnicity, the uniqueness of different patient cohorts, and the challenge ahead for defining set characteristics among populations with significant genetic admixture that define Ph-like ALL risk. The gene discussed is CRLF2; the disease is acute lymphoblastic leukemia.