MC1R and melanoma: Owing to the relative specificity of its expression, MC1R has garnered interest as a potential radiopharmaceutical target for theranostics, the pairing of diagnostics with targeted therapy.21,22 Conventionally, melanoma metastases are detected through noninvasive whole-body imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), and positron-emission tomography (PET).23 In current practice, [18F]fluorodeoxyglucose ([18F]FDG) is employed to assess both the metabolic and structural attributes of metastases.