In our research, CASC11was hypothesized to aggravate diabetic ne phro pathy viatargeting FoxO1, we aim to uncover the potential influencesof CASC11 and FoxO1 on DN progression by collectingclinical samples of DN and generating in vitro HGmodel in kidney mesangial cells. This evidence concerns the gene FOXO1 and liver dysplastic nodule.