NUCB2 and hypothyroidism: Similaly, serum neopterin levels were found to be significantly high in hypothyroidism HT (p 0.001) but its levels in controls, euthyroid HT and HT patients treated with levothyroxine groups were as follows: (21.491.76 nmol/L 4.741.16 nmol/L, 10.491.36 nmol/L, 9.371.21 nmol/L respectively) Significantly lowest level of nesfatin-1 was found in HT whereas its levels in controls, euthyroid HT and HT patients treated with levothyroxine and hypothyroidism HT, groups were (548.46143.03 nmol/L, 205.5724.00 nmol/L, 201.4217.51 nmol/L 116.0319.73, nmol/L respectively) (p<0.001, Table 1).