HAMP and obesity due to melanocortin 4 receptor deficiency: It has been observed that obesity inPCOS patients reduces iron level by increasingcytokines and oxidative stress then raising hepcidin,that prevents iron absorption from the intestine, thusanemia occurs as a risk factor for diabetes and theopposite can also occur where iron rises as a risk factor to type 2 diabetes, insulin resistance and cardiacdisease [16].