CTLA4 and neoplasm: PD-1 mRNA relative fold of change in tumor = 0.71 ± 0.08 (p < 0.05 vs. model group) PD-1 μg/mg protein = 1.67 ± 0.083 (p < 0.01 vs. model group) CTLA-4 mRNA relative fold of change in tumor = 0.63 ± 0.1 (p < 0.05 vs model group) CTLA-4 IOD/106 pixel in tumor = 1066 ± 300