PD-1 mRNA relative fold of change in tumor = 1.45 ± 0.13 PD-1 μg/mg protein = 2.16 ± 0.167 (p < 0.01 vs. model group) CTLA-4 mRNA relative fold of change in tumor = 0.92 ± 0.08 (p < 0.05 vs model group) CTLA-4 IOD/106 pixel in tumor = 400 ± 66.67 Here, CTLA4 is linked to neoplasm.