Koren et al. [57] presented a 38-year-old female without hypoparathyroidism developing hypercalcemia during pregnancy (12.7 mg/dL), alongside suppressed PTH; the authors suggested that this is likely due to PTHrP hypersecretion from the placenta (not measured) and noted significant resistance to conventional treatment (loop diuretics, isotonic saline, and calcitonin), requiring management with pamidronate (levels normalized postpartum). This evidence concerns the gene PTH and hypercalcemia disease.