MITF and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: Translocation RCC (tRCC) represents the subset of sporadic RCC driven by genetic rearrangements of microphthalmia-associated transcription factor (MiTF) family members, such as TFE3 gene on chromosome Xp11 and TFEB on chromosome 6p21.