Previous studies have shown that STMN1 can act as a signature molecule of the PI3K/AKT pathway in breast cancer and pelvic serous carcinomas.[47, 48] We confirmed using bioinformatics analysis and experiments that STMN1 is also important for activating the PI3K/AKT pathway in ICC. The gene discussed is AKT1; the disease is intrahepatic cholangiocarcinoma.