CKM and intrahepatic cholangiocarcinoma: Cytoskeletal reorganization is a characteristic of epithelial–mesenchymal transition (EMT).[26] Using F‐actin staining by phalloidin, we found that cPKM knockdown reduced the formation of filamentous pseudopods in ICC cells, whereas increased formation of filamentous pseudopods was observed after cPKM overexpression (Figure 2C).