CircRNAs can participate in molecular mechanisms regulating tumor progression by interacting with proteins,[29] and we employed multiple online tools, such as CircInteractome (https://circinteractome.irp.nia.nih.gov/), CDSC 2.0 (http://gb.whu.edu.cn/CSCD2/), and RBPmap (http://rbpmap.technion.ac.il/), to identify proteins that potentially interact with cPKM. The gene discussed is CKM; the disease is neoplasm.