TGFB1 is a key molecule in the activation and switching of HSCs to a myofibroblast‐like phenotype.[14, 34, 35] The TGFB1 secreted by tumor cells in the hepatic microenvironment induces the activation of HSCs to produce many extracellular matrix components, such as collagen 1 and fibronectin, promoting dense matrix formation and shaping the microenvironment for tumor progression.[10, 14] Few studies have investigated the factors regulating the level of TGFB1 secreted by tumor cells, and to our knowledge, the role of circRNAs in regulating progress has not been reported in ICC. This evidence concerns the gene TGFB1 and intrahepatic cholangiocarcinoma.