First, we synthesized a folate‐conjugated nanosystem to act as a Trojan horse by loading si‐cPKM and paclitaxel, the two “pioneer soldiers.” Taking advantage of the high penetration and targeting properties of nanoparticles, the nanosystem brought them safely and effectively into the solid ICC tumor like the city of Troy. Here, CKM is linked to intrahepatic cholangiocarcinoma.