The si‐cPKM/PTX co‐loaded nanoparticles (Trojan horse) efficiently deliver si‐cPKM and paclitaxel (soldiers) into ICC, promote paclitaxel sensitization, suppress ICC proliferation and metastasis, and reopen collapsed tumor vessels (opening the gates), thus enhancing the efficacy of the standard chemotherapy regimen (main force). Here, CKM is linked to intrahepatic cholangiocarcinoma.