High STMN1 levels have been detected in various malignancies, and they are associated with accelerated tumor progression.[21, 23, 41, 42] In addition, STMN1 is an important response factor to clinical chemotherapy in patients with paclitaxel‐resistant tumors and is closely associated with chemoresistance of tumors.[22, 23] However, to our knowledge, the expression level and the role of such an important cancer‐related protein in intrahepatic cholangiocarcinoma have not been reported so far. This evidence concerns the gene STMN1 and intrahepatic cholangiocarcinoma.