Immunofluorescence (IF) staining for α‐SMA confirmed that knockdown (KD)‐cPKM ICC cells caused less myofibroblast activation in HSCs, whereas overexpressing (OE)‐cPKM ICC cells induced more myofibroblast activation in HSCs (Figure 2F). Here, CKM is linked to intrahepatic cholangiocarcinoma.