Previous studies have shown that STMN1 plays an important role in tumor proliferation and metastasis[21, 23] and that TGFB1 is an important cytokine for myofibroblast activation in HSCs.[14, 34, 35] Based on the abovementioned findings, we hypothesized that cPKM increased the expression and secretion of TGFB1 to promote HSC myofibroblast activation by interacting with IGF2BP2. This evidence concerns the gene STMN1 and neoplasm.