The folate receptor (FR) is overexpressed in many human cancers and has become a useful target for tumor‐specific drug delivery.[43] Analysis using the GEPIA2 database showed that FOLR1 (FR alpha) was significantly upregulated in cholangiocarcinoma tissues (Figure S6A, Supporting Information), and thus, we used folate‐conjugated DSPE‐PEG (2000) for targeting ICC cells. This evidence concerns the gene FOLR1 and intrahepatic cholangiocarcinoma.