The expression levels of STMN1 were correlated with paclitaxel resistance.[22, 23] We performed live/dead cell double staining of ICC microtumor spheroids under paclitaxel treatment and found that the resistance of ICC microtumor spheroids to paclitaxel was reduced after STMN1 knockdown but increased after STMN1 overexpression (Figure 5E). Here, STMN1 is linked to intrahepatic cholangiocarcinoma.