However, Pontecorvi, P et al. has found that the expression of protein kinase X (PRKX) is increased in vaginal keratinocytes from MRKH patients and PRKX overexpression significantly affect the expression of HOX genes (Pontecorvi, Bernardini, et al., 2021; Pontecorvi, Megiorni, et al., 2021). The gene discussed is PRKX; the disease is Mayer-Rokitansky-Kuster-Hauser syndrome.