These include DOCK2, which is known to activate RAC1/RAC2 genes required for implantation (Kunisaki et al. 2006; Grewal et al. 2008), and TRIM25, a gene involved in innate immune response against viral infection, mediating estrogen action and whose downregulation during embryogenesis in medaka has been shown to result in apoptosis (Gack et al. 2007; Dong et al. 2012; Zhang et al. 2015). This evidence concerns the gene TRIM25 and viral infectious disease.