The current MR study demonstrated that genetically proxied higher circulating IL14 level was causally associated with an increased risk of IPF, whereas no significant associations were found between genetically higher exposures of other circulating inflammatory cytokines levels (circulating CRP, MIP1a, MIP1b, IL-1ra, IL-2ra, IL-2, IL-6, IL-8, IL-10, IL-13, IL-16, IL-17, IL-18, MCP1, MIF, Eotaxin, GROa, MIP1a, MIP1b, RANTES, TANLN, CXCL9, TNFa, TNFb) and IPF. Here, TXLNA is linked to idiopathic interstitial pneumonia.